One Medicine Projects

Background: Veterinarians routinely use human antifungal drugs to treat dogs with Valley Fever, as there are no approved veterinary drugs for this condition.  There is also a rise in antifungal drug resistance which is of significant concern in human and veterinary medicine.   OMG seeks to leverage the immune system to help fight infection, based on a growing body of evidence immune modulation can shorten the duration of VF, even in patients that are severely ill and refractory to antifungal therapy.
Study: This study will evaluate clinical and immunological responses in dogs administered orally bioactive immune modulators in conjunction with antifungal therapy.
Immune Modulators: OMG has selected immune modulators with comparable mechanisms of actions in people and dogs, making this study highly translatable.
Eligibility: Dogs with diagnosed with Valley Fever that are over 1 year of age with clinical signs of disease (e.g., coughing, limping, fever, lethargy).
Owner responsibilities:  Owners will receive treatments (e.g., fluconazole plus an immune modulator) at no cost for the first 30 days.
Owners will be responsible for the cost of routine (standard of care) exams and bloodwork (e.g., Valley Fever titers) which will be explained during the first visit.